neurotoxicity perspective: stand behind prograf® (tacrolimus) as a pharmacist
نویسندگان
چکیده
منابع مشابه
Immunosuppression with tacrolimus early after orthotopic heart transplantation: a comparison of prograf and advagraf.
BACKGROUND We compared trough levels and clinical outcomes in patients who received Prograf or Advagraf (tacrolimus) de novo following heart transplantation surgery. METHODS Eighty-two patients were included in this follow-up study. Biopsy results were controlled for the first 3 months after orthotopic heart transplantation. Trough levels were monitored for 4 weeks: daily during the first 7 d...
متن کاملProtocol biopsy and subclinical rejection in patients after kidney transplantation treated by tacrolimus (Prograf).
The article deals with the contribution of tacrolimus (Prograf) to improvement in kidney transplant results. Tacrolimus, in comparison with cyclosporine significantly reduces the incidence of acute rejection and improves survival of grafts as well as patients. Based on the literature, the primary immunological differences between tacrolimus and cyclosporine effects are pointed out. These differ...
متن کاملShort-Term Outcomes in Heart Transplant Recipients Treated with Generic Tacrolimus Compared to Prograf
Calcineurin inhibitors are the cornerstone of solid organ transplant immunosuppression. Tacrolimus has only recently become available in a non-branded formulation, and there is little data on the efficacy and safety of generic tacrolimus, particularly following heart transplant. We performed a retrospective analysis of 21 consecutive patients who were treated with generic tacrolimus following h...
متن کاملPearls & Oy-sters: Tacrolimus neurotoxicity presenting as an isolated brainstem lesion.
• Tacrolimus is an immunosuppressive agent that inhibits the activity of calcineurin. Neurologic adverse effects are varied and manifest irrespective of tacrolimus levels. These can include minor headaches and tremor to more severe seizures, cortical blindness, and coma. • Tacrolimus-associated brainstem neurotoxicity is a rarely documented phenomenon that should be considered in the differenti...
متن کاملReversible tacrolimus-induced neurotoxicity isolated to the brain stem.
Diplopia, nystagmus, visual hallucinations, and internuclear ophthalmoplegia developed in a 30-year-old woman 84 days after she received a matched, unrelated bone marrow transplant for chronic myeloid leukemia. A regimen of tacrolimus had been administered since the transplantation was performed. MR imaging revealed bilaterally symmetric regions of signal abnormality with abnormal contrast enha...
متن کاملComparison of the long-term efficacy and safety of generic Tacrobell with original tacrolimus (Prograf) in kidney transplant recipients
This study aimed to evaluate the long-term efficacy and safety of a generic tacrolimus (Tacrobell [TCB]) compared to the original tacrolimus (Prograf [PGF]) in kidney transplant recipients. In this retrospective observational study, we analyzed the data from 444 patients who took TCB as a first-line immunosuppressive drug and 245 patients who took PGF. The 5-year graft survival rate was 92% for...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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